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Hydergine pharmacokinetics in the elderly.

D Lavène, H Humbert, J R Kiechel

    Journal De Pharmacologie
    |January 1, 1985
    PubMed
    Summary

    Pharmacokinetics of Hydergine in elderly individuals show reduced renal and metabolic clearance, with increased oral bioavailability. These findings highlight the importance of studying geriatric drug kinetics in the target population.

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    Area of Science:

    • Geriatric Pharmacology
    • Drug Metabolism
    • Clinical Pharmacokinetics

    Background:

    • Aging significantly alters physiological functions, impacting drug pharmacokinetics.
    • Hydergine is commonly prescribed for elderly individuals, necessitating understanding of its drug behavior in this population.

    Purpose of the Study:

    • To investigate the pharmacokinetics of Hydergine in elderly subjects.
    • To compare Hydergine's renal and metabolic clearance, and oral bioavailability between elderly individuals and younger controls.

    Main Methods:

    • Intramuscular and oral administration of Hydergine in elderly subjects (n=12, aged 66-86).
    • Comparison with a control group of healthy young volunteers (n=6, average age 25).
    • Analysis of renal clearance, metabolic clearance, and oral bioavailability.

    Main Results:

    • Elderly subjects exhibited a 50% reduction in renal clearance, correlated with decreased creatinine clearance.
    • Metabolic clearance was lowered by 30% in elderly subjects, likely due to reduced hepatic blood flow.
    • Oral bioavailability increased 2.5-fold in elderly individuals, potentially due to enhanced absorption or reduced first-pass metabolism.

    Conclusions:

    • Hydergine pharmacokinetics are significantly altered in the elderly population.
    • Reduced renal and metabolic clearance, alongside increased oral bioavailability, are key findings in geriatric Hydergine use.
    • These results underscore the necessity of pharmacokinetic studies in the specific target geriatric population for appropriate drug dosing and efficacy.

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