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Identifying Adherence Trajectories in Chronic Hepatitis B: A Cluster-Based Approach to Long-Term Treatment Management

Lin Zhang1, Huichun Ji1, Suhua Pang1

  • 1Department of Infectious Diseases, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, China.

Journal of Viral Hepatitis
|September 13, 2025
PubMed

Insights

Medication adherence in chronic hepatitis B (CHB) patients shows varied patterns over time. Psychosocial factors like self-efficacy, social support, stigma, and depression significantly impact adherence, highlighting the need for targeted interventions.

Area of Science:

  • Hepatology
  • Psychology
  • Public Health

Background:

  • Chronic hepatitis B (CHB) requires long-term medication adherence for effective management.
  • Understanding adherence patterns and influencing factors is crucial for treatment optimization.

Purpose of the Study:

  • To investigate medication adherence levels and longitudinal trajectories in CHB patients.
  • To identify key psychosocial factors affecting adherence.
  • To provide evidence for strategies to improve adherence and quality of life.

Main Methods:

  • Longitudinal study with 305 CHB patients over 12 months.
  • Data collection on medication adherence and psychosocial factors at multiple time points.
  • K-means cluster analysis to identify adherence patterns and associated psychosocial characteristics.

Main Results:

  • Four distinct adherence trajectories were identified: improvement, low adherence, decline, and high adherence.
  • Significant differences in adherence scores and psychosocial factors were observed across trajectories (p < 0.05).
  • Higher adherence correlated with greater self-efficacy and social support; lower adherence linked to increased stigma and depression.

Conclusions:

  • Medication adherence in CHB patients is dynamic and significantly influenced by psychosocial factors.
  • Interventions targeting psychological support, stigma reduction, and social support networks are recommended.
  • Improving adherence can enhance treatment outcomes and patient quality of life.

Keywords:
chronic hepatitis Bcluster analysismedication adherencepsychosocial factors

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