Related Experiment Video
Updated: Jan 6, 2026
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Novel BMPR1B::AFF2 in a Sinonasal Region Non-Keratinizing Squamous Cell Carcinoma
Tyler R Selkin1, Varsha Manucha2, Jing Xu1
1Department of Pathology, University of Texas Southwestern Medical Center, 6201 Harry Hines Blvd., Dallas, TX, 75390, USA.
Introduction:
Molecular diagnostic tools may help resolve difficult differential diagnoses, and in some cases, they uncover entirely novel findings.
Methods:
We performed immunohistochemistry and molecular analysis on a cytologically bland squamous tumor of the sinonasal region.
Results:
We found a previously unreported BMPR1B::AFF2 fusion in a difficult-to-characterize nasal and nasopharyngeal tumor exhibiting aggressive local behavior and recurrence.
Conclusion:
While the DEK::AFF2 fusion is well-characterized in sinonasal region tumors, alternate fusion partners are becoming increasingly recognized.
Related Concept Videos
02:23Abnormal Proliferation
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:30Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...