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Three new phenanthrene derivatives from Pinalia densa and their cytotoxic activity against human prostate cancer
Suthathip Ploithoom1,2, Narumol Bhummaphan3, May Thazin Thant2
1Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Abstract:
Phytochemical analysis on the entire plant of Pinalia densa disclosed the existence of three new phenanthrene derivatives, named pinadensins A-C (1-3), in addition to ten known compounds (4-13). Structural elucidation of all new compounds was accomplished by several interpreting spectroscopic data such as CD, MS and NMR. Pinadensin A (1) and 9,9'-O-di-(E)-feruloyl-(-)-secoisolariciresinol (12) induced cytotoxic effects in human prostate cancer cell lines (PC-3 and DU145) as well as human normal keratinocyte HaCaT cells in relation to the dose; with an IC50 value of 30.97 ± 9.0 μM, liparisphenanthrene B (11) demonstrated significant cytotoxic action on PC-3, while having a less cytotoxic impact on HaCaT cells.
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