Evaluation of Bisphenol A Levels in Children With Unprovoked Seizures

Bisphenol A (BPA) is a widely used chemical in plastics and epoxy resins, with potential neurotoxic effects. Limited evidence links BPA exposure to seizures, yet the mechanisms remain unclear.

This study aimed to investigate the relationship between urinary BPA levels and unprovoked seizures in children.

Urine samples from children presenting with seizures and age-matched healthy control subjects were analyzed for BPA levels. BPA/body surface area (BSA) ratios and creatinine-indexed BPA levels were calculated. Statistical comparisons were made to assess associations between BPA exposure and seizure incidence.

The mean urinary BPA levels were significantly higher in the control group (0.067 ± 0.057 μg/mL) compared with the patient group (0.029 ± 0.322 μg/mL; P = 0.024). No significant differences were observed between the groups for BPA/BSA ratios (P = 0.463) or creatinine-indexed BPA levels (P = 0.452). Although higher BPA levels were noted in younger children, no significant association was found between BPA levels and seizure type or recurrence.

The study highlights discrepancies in BPA measurement methods and suggests age and body composition as critical factors influencing BPA levels. Although no direct link between BPA and seizures was established, the results underscore the importance of standardized methods for BPA assessment and the need for larger studies to explore potential neurotoxic effects.