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Deciphering inulin from Jerusalem artichoke: Extraction, structural characteristics, bioactivities,
Zihao Wang1, Na Ling1, Chunqiu Guo1
1Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin 150076, China; Engineering Research Center for Natural Antitumor Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China.
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|September 13, 2025
Summary
Jerusalem artichoke inulin (JAI) is a valuable dietary fiber with significant health benefits, including blood glucose and lipid regulation. This review details JAI
Area of Science:
- Nutritional Science
- Biochemistry
- Pharmacology
Background:
- Jerusalem artichoke inulin (JAI) is a high-quality dietary fiber with recognized pharmacological functions.
- JAI plays a role in lowering blood glucose and lipids, regulating gut microbiota, and supporting immune function.
- Understanding JAI's structure and bioactivities is crucial for its development and application.
Purpose of the Study:
- To comprehensively review advancements in JAI extraction, purification, and structural characteristics.
- To summarize the biological activities, structure-activity relationships, and modification of JAI.
- To elucidate JAI's pharmacokinetics, safety, and potential applications in various industries.
Main Methods:
- Literature review of diverse databases (PubMed, Web of Science, ScienceDirect, CNKI).
- Compilation of information on JAI extraction, purification, structural characterization, bioactivities, pharmacokinetics, and safety.
- Analysis of structure-activity relationships and structural modifications.
Main Results:
- JAI can be extracted using methods like hot water, ultrasonic, and microwave-assisted extraction.
- Analytical techniques (GC-MS, HPLC, FT-IR, NMR) characterize JAI's polymerization degree, molecular weight, and structure.
- JAI exhibits bioactivities including gut microbiota regulation, blood glucose/lipid reduction, immune enhancement, and mineral absorption promotion.
- Structure-activity relationships and modifications (chemical, physical, biological) enhance JAI's properties.
- Pharmacokinetics and safety data support JAI's use in food, pharmaceuticals, and biomedical fields.
Conclusions:
- Extraction and structural elucidation of JAI provide a foundation for its utilization.
- JAI demonstrates significant biological attributes, including gut microbiota modulation, immunomodulation, and metabolic benefits.
- Structure-activity relationships and modifications offer insights into JAI's interactions and potential.
- Pharmacokinetics and safety assessments confirm JAI's applicability in food and pharmaceutical sectors.
Keywords:
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