Related Experiment Video
Updated: Jul 23, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
Molecular networking and deep learning synergy for bioactive metabolite discovery in L. plantarum-Fermented Sea
Zhihui Luo1, Fengling Liu1, Shan Du1
1School of Food and Biotechnology, Xihua University, No.999 Guangchang Road, Chengdu 610039, China.
Abstract:
This study investigated the metabolomic transformation of sea buckthorn milk fermented by Lactiplantibacillus plantarum to identify novel bioactive compounds and improve both nutritional and sensory attributes. An untargeted metabolomics workflow integrating Feature-Based Molecular Networking (FBMN) with deep learning was developed to overcome the annotation limitations of conventional database-driven approaches. Using this strategy, 179 metabolites were characterized, including two previously unreported isovaleryl-flavonol glycosides and tetrahydroharman-3-carboxylic acid. Time-course analysis revealed marked enrichment of health-promoting flavonoids, accompanied by significant reductions in fumaric acid and D-(+)-malic acid-changes correlated with improved flavor and mouthfeel. This work demonstrates, for the first time, the capability of an FBMN-deep learning pipeline to map bioactive metabolite dynamics in a food matrix, offering a robust methodological framework for accelerating functional compound discovery and guiding the formulation of next-generation health-oriented fermented beverages.
More Related Videos
08:20Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
11:06Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
Related Concept Videos
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Microbial Interactions: Cooperation
Microbes in Food Production
Microbes in the Production of Fermented Foods
Production of Organic Acids
iChip