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Microfluidics in Assessing Platelet Function
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Platelets loaded with alteplase exert fibrinolytic activity in human whole blood and plasma

Masataka Inoue1, Masahiro Ohwada1, Teruhiko Negishi2

  • 1Functional Control Systems, Graduate School of Engineering and Science, Shibaura Institute of Technology, Saitama, Japan.

Experimental Hematology
|September 13, 2025
PubMed

The utilization of alteplase for the management of intracerebral thromboembolism is associated with an elevated risk of intracerebral hemorrhage. To mitigate this risk, we investigated the fibrinolytic effect of alteplase-loaded platelets as a preliminary step in the development of a biocompatible drug delivery system (DDS). In this context, we demonstrated that platelet loaded with alteplase exhibited thrombolytic efficacy. Therefore, a drug DDS that employs alteplase-loaded platelets may offer a promising avenue for the development of a more biocompatible and less invasive thrombolytic therapy.

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