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Mechanisms of tumor aggressiveness driven by ablation-induced niche remodeling

Shuyue Gao1, Ting Luo2, Fangying Fan2

  • 1Senior Department of Oncology, Chinese PLA General Hospital, Beijing, China; Chinese PLA Medical School, Beijing, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|September 13, 2025
PubMed

Insights

Ablation-induced niche remodeling can unexpectedly increase tumor aggressiveness by promoting cell death resistance, immune suppression, and enhanced migration. Understanding these mechanisms is crucial for developing better cancer therapies.

Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Microenvironment Research

Background:

  • The tumor microenvironment is a complex interplay between tumor cells and surrounding stroma.
  • Tumor niche remodeling after ablation therapies can paradoxically enhance tumor aggressiveness.
  • Understanding these changes is critical for improving cancer treatment outcomes.

Purpose of the Study:

  • To review current knowledge on ablation-induced niche remodeling in tumor progression.
  • To identify research trends and hotspots in this field via bibliometric analysis.
  • To explore the biological mechanisms driving niche remodeling post-ablation.

Main Methods:

  • Bibliometric analysis of research trends and hotspots.
  • Review of biological mechanisms of niche remodeling.
  • Focus on resistance to cell death, immune cell reprogramming, and tumor invasiveness.

Main Results:

  • Bibliometric analysis highlights key research areas and trends.
  • Niche remodeling post-ablation involves resistance to cell death.
  • It also includes immune cell reprogramming towards immunosuppression.
  • Enhanced tumor invasiveness and migration are observed.

Conclusions:

  • Ablation-induced niche remodeling significantly contributes to tumor progression.
  • Mechanisms include enhanced cell death resistance, immune evasion, and increased metastasis.
  • These findings are vital for future research and clinical strategy development.
Keywords:
Ablation techniquesNiche remodelingTumor aggressivenessTumor microenvironment

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