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SPARC: The Standardised Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Analysis
Ken Herrmann1, Jochen Walz2, Steven MacLennan3
1Department of Nuclear Medicine, University of Duisburg-Essen, Essen, Germany; German Cancer Consortium (DKTK) University Hospital Essen, Essen, Germany.
European Urology
|September 13, 2025
Summary
Standardised Prostate-Specific Membrane Antigen (PSMA) PET/CT reporting guidelines were developed by experts. The SPARC project established consensus on PSMA PET/CT analysis and reporting frameworks for improved prostate cancer diagnosis and management.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is an evolving diagnostic tool for prostate cancer.
- There is a need to harmonize existing guidelines and reporting recommendations for PSMA PET/CT.
Purpose of the Study:
- The Standardised PSMA PET/CT Analysis and Reporting Consensus (SPARC) project aimed to consolidate classifications and recommendations from a multidisciplinary and international group of experts.
- To establish a dynamic and evolving structure for PSMA PET/CT reporting.
Main Methods:
- A cross-sectional iterative process involving a 30-member expert panel was employed.
- A modified Delphi survey with 91 statements was conducted, analyzed using the RAND appropriateness method.
- International multidisciplinary prostate cancer expert groups convened for literature review and statement formulation.
Main Results:
- Consensus increased to 93% between two rounds of the Delphi survey.
- The panel endorsed frameworks for reporting PSMA expression, miTNM by PROMISE, PRIMARY score, PSMA volume, and standardized uptake values (SUVmax) regionally.
- Uncertainty remains regarding correlation with conventional imaging risk groups and the impact of PSMA PET/CT on clinical management outcomes.
Conclusions:
- SPARC provides a standardized PSMA PET/CT analysis and reporting consensus for future reference.
- Integrating common PSMA PET reporting criteria improves communication between imaging experts and clinicians for better clinical implementation.
