Cardiac Autonomic Dysfunction and Peri-Operative Outcomes Among Elective Neurosurgical Patients: Secondary Analysis...

Area of Science:

• Neurosurgery
• Cardiology
• Autonomic Nervous System

Background:

• Cardiac autonomic dysfunction (CAD) is common in Indian neurosurgery patients.
• Cranial lesions may affect autonomic circuits, impacting hemodynamic responses.
• CAD's role in neurosurgical perioperative adverse cardiac events (PACE) is unclear.

Purpose of the Study:

• Evaluate the impact of preoperative CAD on PACE composite scores.
• Assess CAD's effect on PACE, mortality, hospital stay, and GCS.
• Analyze autonomic nervous system (ANS) function in neurosurgical patients.

Main Methods:

• Prospective observational study of 400 adult neurosurgery patients.
• Preoperative CAD assessed using ANSiscope™ heart rate variability indices.
• Analysis of perioperative hemodynamic profile and clinical outcomes.

Main Results:

• No significant difference in median PACE composite scores across CAD groups.
• Intraoperative hemodynamics and early postoperative PACE were similar.
• Mortality, hospital stay, and discharge GCS scores did not differ between groups.

Conclusions:

• Preoperative cardiac autonomic dysfunction, assessed by ANSiscope™, did not influence perioperative adverse cardiac events.
• CAD did not impact mortality, length of hospital stay, or GCS scores in this cohort.
• The study found no significant association between CAD and clinical outcomes in neurosurgery.