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Updated: Jan 17, 2026

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
Published on: April 5, 2016
Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional
Amar Ojha1, Will Foran2, Finnegan J Calabro3
1Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
Abstract:
Adolescent neurodevelopment of affective and cognitive control, crucial for healthy functioning and impaired transdiagnostically, is supported by refinements between the amygdala and prefrontal cortex (PFC). Due to technical limitations, fronto-amygdala connectivity remains poorly characterized. Here, we leverage multimodal longitudinal 7 T neuroimaging data in 143 healthy participants aged 10-32 to examine developmental trajectories between subject-specific amygdala nuclei and PFC subregions. We find age-related functional connectivity changes between the lateral PFC and basolateral amygdala, ventral portions of the PFC and central amygdala, and the anterior cingulate cortex and corticoamygdaloid transition area. Variability in connectivity strength relates to individual differences in affective and cognitive control. Using a data-driven meta-analytic decoding approach, we find functional specialization across nuclei and development. Together, these data recapitulate amygdala heterogeneity from animal models and inform how diverse subcircuits support adaptive functioning and confer psychiatric risk during developmental windows of heightened plasticity.
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