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Related Experiment Video

Updated: Jan 17, 2026

Co-staining Blood Vessels and Nerve Fibers in Adipose Tissue

Co-staining Blood Vessels and Nerve Fibers in Adipose Tissue

Published on: February 13, 2019

Vasoactive Intestinal Peptide: Another Player in Adipose Tissue Blood Flow Regulation?

Richard Sotorník¹, Julie Ménard², Pascal Brassard¹

¹Division of Endocrinology, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.

Microcirculation (New York, N.Y. : 1994)

|September 14, 2025

Summary

Vasoactive intestinal peptide (VIP) effectively increases adipose tissue blood flow (ATBF) in healthy individuals. However, some people show a reduced ATBF response to VIP, potentially linked to cardiometabolic risk.

Keywords:

133Xenon washout adipose tissue blood flow gastrointestinal tract vasoactive intestinal peptide

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Published on: July 21, 2023

Area of Science:

Physiology
Metabolism
Cardiovascular Health

Background:

Adipose tissue blood flow (ATBF) normally increases after meals, but this response is impaired in about one-third of healthy individuals.
This impaired ATBF response is associated with prolonged postprandial lipemia and elevated cardiometabolic risk.
Vasoactive intestinal peptide (VIP), a gut neurotransmitter, possesses vasodilatory properties.

Purpose of the Study:

To investigate the role of VIP in regulating ATBF.
To determine if VIP contributes to the blunted postprandial ATBF response observed in some individuals.

Main Methods:

Assessed plasma VIP levels and ATBF using the 133Xenon washout technique after an oral glucose load in 16 healthy participants.
Measured ATBF during in situ microinfusion of varying VIP doses in 12 participants.

Main Results:

Oral glucose did not alter plasma VIP levels.
VIP microinfusion significantly increased ATBF in a dose-dependent manner (p < 0.0001).
Individuals with a blunted post-glucose ATBF response showed a trend towards a lower response to VIP.

Conclusions:

VIP demonstrates a potent vasodilatory effect on adipose tissue.
A diminished response to VIP may contribute to the blunted ATBF observed in certain individuals.
Further research in larger cohorts is needed to confirm the role of local VIP unresponsiveness in this non-responder status.