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Related Experiment Videos

Polymers of biogenic amines.

J B Richardson, T Bouchard, G N Boyd

    Canadian Journal of Physiology and Pharmacology
    |August 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Biogenic amines reacted with glutaraldehyde formed precipitates with biological activity. However, these amine-glutaraldehyde polymers were unstable, limiting their use for amine localization but suggesting potential as depot drugs.

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    Area of Science:

    • Biochemistry
    • Polymer Chemistry
    • Pharmacology

    Background:

    • Biogenic amines are crucial signaling molecules.
    • Glutaraldehyde is a cross-linking agent.
    • Understanding amine-polymer interactions is important for biological applications.

    Purpose of the Study:

    • To investigate the reaction of biogenic amines with glutaraldehyde.
    • To characterize the resulting precipitates and their biological activity.
    • To assess the stability and potential applications of these polymers.

    Main Methods:

    • Reaction of primary amino group-containing biogenic amines with glutaraldehyde.
    • Ultrastructural analysis of precipitates using osmic acid.
    • In vitro testing of biological activity.

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  • Isotope-labeled amine experiments to assess polymer stability.

    • Main Results:

    • Insoluble precipitates formed from biogenic amines and glutaraldehyde.
    • Precipitates exhibited distinct ultrastructural features and in vitro biological activity.
    • A significant portion of the biological activity was attributed to the amine-glutaraldehyde polymer.
    • Isotope labeling revealed instability, with free amine liberation from the polymers.

    Conclusions:

    • The amine-glutaraldehyde precipitates were not stable enough for morphological amine localization.
    • The polymers showed potential utility as depot drugs.
    • These precipitates may be useful for developing vaccines against biogenic amines through animal immunization.