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Forming Giant-sized Polymersomes Using Gel-assisted Rehydration
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Polymer vesicle microreactors produced using permeable polymer blocks: Circumventing complex functionality to impart

Anabella P Rosso1, Martina Vragovic2, Rafal Konefal3

  • 1Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, Brazil.

Journal of Colloid and Interface Science
|September 14, 2025
PubMed
Summary
This summary is machine-generated.

Giant vesicles were synthesized using block copolymers for controlled biochemical reactions. pH-responsive vesicles demonstrated selective permeability, enabling applications as microreactors for biocatalysis.

Keywords:
Block copolymersGiant polymer vesiclesMicroreactorsSelf-assembly

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Area of Science:

  • Materials Science
  • Biochemistry
  • Chemical Engineering

Background:

  • Giant vesicles offer potential as microreactors due to compartmentalization and tunable permeability.
  • Mimicking natural cellular compartments, these vesicles are promising for catalysis, drug delivery, and synthetic biology.

Purpose of the Study:

  • To synthesize giant vesicles using amphiphilic block copolymers.
  • To investigate the properties and potential of these vesicles as microreactors, particularly focusing on pH-responsive variants.

Main Methods:

  • Synthesized giant vesicles via double emulsification using five amphiphilic block copolymers with varying hydrophobic blocks (PCL, PMMA, PLA, PDPA, PHIA).
  • Characterized vesicle formation using optical and fluorescence microscopy with Nile red.
  • Demonstrated encapsulation of large molecules (BSA-Alexa) and catalytic activity (HRP) within the vesicles.

Main Results:

  • Successfully produced giant vesicles with sizes ranging from 2.9 to 9.3 μm.
  • pH-responsive vesicles (PDPA, PHIA) showed larger diameters and selective permeability to reactants (H₂O₂, o-dianisidine) for HRP-catalyzed reactions.
  • Non-responsive vesicles (PCL, PMMA, PLA) exhibited negligible permeability, even at optimal enzyme pH.

Conclusions:

  • pH-responsive giant vesicles can be synthesized using block copolymers.
  • These vesicles exhibit controlled molecular transport, making them suitable for microreactor applications in biocatalysis.
  • The tunable permeability of pH-responsive vesicles opens avenues for advanced controlled reaction systems.