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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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Published on: July 19, 2019

Baló's concentric sclerosis: A retrospective case series.

Henry Peraza¹, John Rees², Jesse Kresak³

¹Department of Neurology, College of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA.

Multiple Sclerosis and Related Disorders

|September 14, 2025

Summary

Baló

Keywords:

Baló’s concentric sclerosis Disease modifying therapy Multiple sclerosis Optic neuritis

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Area of Science:

Neurology
Immunology
Demyelinating Diseases

Background:

Baló's concentric sclerosis (BCS) is a rare autoimmune demyelinating disease.
BCS is characterized by a distinct concentric ring-like pattern of demyelination.

Purpose of the Study:

To evaluate the clinical features of Baló's concentric sclerosis.
To assess disease progression and treatment responses in BCS patients.

Main Methods:

Single-center retrospective study.
Inclusion criteria: ICD-10 code G37.5 (BCS) between October 1, 2015, and June 30, 2024.
Analysis of clinical presentations, lesion patterns, disability scores, and treatment outcomes.

Main Results:

14 BCS patients identified (median age 41, 86% female).
Common initial presentations: optic neuritis (57%), brainstem syndrome (29%).
High relapse rates observed with glatiramer acetate and natalizumab; no relapses with anti-CD20 therapies (ocrelizumab, rituximab).

Conclusions:

Baló's concentric sclerosis may have a favorable clinical course.
Anti-CD20 therapy appears highly effective in preventing relapses in BCS patients.