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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Phases of Wound Repair01:28

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Related Experiment Video

Updated: Jan 17, 2026

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
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Electrosprayed hydrogel microsphere dressing promotes vascularization and accelerates wound healing.

Qilong Wang1, Zeyu Xu2, Xuedi Weng1

  • 1Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, China; Medicinal function development of New Food Resources, Jiangsu Provincial Research Center, Jiangsu, China.

Acta Biomaterialia
|September 14, 2025
PubMed
Summary

This study developed a novel hydrogel dressing using electrostatic spraying to encapsulate ectodermal mesenchymal stem cells (EMSCs). The optimized dressing promotes vascularization and accelerates healing in severe skin injuries.

Keywords:
Dopamine-modified hyaluronic acid (HADA)Ectodermal mesenchymal stem cells (EMSCs)Electrostatic sprayingHAMA hydrogel microspheresVascular regeneration

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Neovascularization is critical for skin injury repair, but severely damaged wounds often exhibit impaired vascularization.
  • Current treatments struggle to promote adequate blood vessel formation in complex wounds, hindering effective healing.
  • Developing advanced wound dressings that support angiogenesis is essential for treating severe skin injuries.

Purpose of the Study:

  • To fabricate and optimize a hydrogel dressing for enhanced skin repair by promoting neovascularization.
  • To encapsulate ectodermal mesenchymal stem cells (EMSCs) within methacrylated hyaluronic acid (HAMA) microspheres using electrostatic spraying.
  • To improve the adhesive and mechanical properties of the hydrogel dressing for better integration and efficacy.

Main Methods:

  • Electrostatic spraying was used to create HAMA microspheres encapsulating EMSCs.
  • Process parameters were optimized to ensure EMSC biocompatibility and differentiation into vascular structures in vitro.
  • Dopamine-modified hyaluronic acid (HADA) was incorporated to enhance dressing adhesion and mechanical properties (using PVAMA).

Main Results:

  • Successfully fabricated biocompatible EMSC-laden HAMA microspheres.
  • Optimized HADA modification improved the adhesive and mechanical properties of the hydrogel dressing.
  • The composite dressing promoted in vitro microvascular network formation.
  • In vivo studies showed the dressing integrated with tissues, modulated inflammation, and accelerated wound healing in mice.

Conclusions:

  • A composite hydrogel dressing integrating cell-laden microspheres and adhesive hydrogels effectively promotes skin microvascularization.
  • The optimized dressing demonstrates significant potential for accelerating wound healing and clinical applications in tissue engineering.
  • This approach offers a promising strategy for treating severe skin injuries requiring enhanced regenerative capabilities.