The nasal microbiome, inhalation exposure, and brain toxicity: A commentary

Area of Science:

• Neuroscience and Microbiology
• Focus on the intersection of the nasal microbiome and neurotoxicity.

Background:

• The microbiome's role in nervous system diseases is gaining attention.
• Nasal microbiome's connection to neurotoxicity remains under-explored.
• Inhalation of xenobiotics is linked to neurodegenerative diseases.

Purpose of the Study:

• To highlight the potential of nasal microbiome research in understanding neurotoxicity.
• To propose the nasal microbiome as a key area for future investigation.

Main Methods:

• This is a commentary, not an experimental study.
• Synthesizing current knowledge on the nasal microbiome and neurotoxicity.

Main Results:

• The nasal microbiome is largely unexplored in the context of neurotoxicity.
• A potential link exists between nasal microbiome dysbiosis and neurotoxicity from inhaled xenobiotics.

Conclusions:

• Research into the nasal microbiome offers a significant opportunity to understand the neurotoxic effects of inhaled xenobiotics.
• Further investigation is warranted to explore this connection and its implications for neurodegenerative diseases.