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Updated: May 11, 2026

Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface
Published on: October 8, 2013
The nasal microbiome, inhalation exposure, and brain toxicity: A commentary
Christine Frieke Kuper1, Eva A J Rennen2, Wolfgang Kaufmann3
1Independent consultant, Haagstraat 13, Utrecht 3581SW, the Netherlands.
Abstract:
The microbiome is increasingly discussed in diseases of the nervous system. The nasal microbiome is largely unexplored in neurotoxicity, while inhalation exposure to xenobiotics has been associated with neurodegenerative diseases linked to neurodegenerative diseases that are a growing health problem. The concept of a link between pathological changes of the nasal microbiome (dysbiosis) and brain neurotoxicity upon inhalation exposure is still in its early stages. In this commentary we argue that research into the nasal microbiome offers a great opportunity to obtain important information about the neurotoxicity of inhaled xenobiotics.
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