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Zhenqi Buxu oral liquid ameliorates inflammaging and aging associated dysfunction via downregulation of
Xinqing Jiang1, Weidong Ye2, Zhengkai Wang3
1Jinhua Graduate Joint Training Base, Zhejiang Chinese Medical University, Quzhou People's Hospital, Quzhou, 324000, China.
Ethnopharmacological Relevance:
Aging is associated with a persistent, low-grade inflammatory state termed "inflammaging", driven by the accumulation of senescent cells and their senescence-associated secretory phenotype (SASP). Zhenqi Buxu Oral Liquid (ZQBX) is a widely used traditional Chinese medicine formula known to treat human weakness and have potential anti-aging effects.
Aim Of Study:
To explore the geroprotective effects of ZQBX and its underlying mechanisms.
Methods:
We used a natural aging mouse model to evaluate the effects of ZQBX intervention on aging. Tissue staining, serum ELISA assays, physical function analysis, network pharmacological analysis and molecular docking analysis were employed to describe the phenotypic and mechanistic effects of ZQBX.
Results:
ZQBX treatment protected against age-related declines in liver function and hepatic steatosis, mitigated chronic inflammation, and improved insulin sensitivity and glucose metabolism in aged mice. Mechanically, ZQBX reduced SASP in senescent hepatic cells to delay liver aging through inhibiting the TNF-α signaling pathway.
Conclusion:
The pharmacological significance of ZQBX in modulating senescence-associated phenotypes implies its potential benefits in regulating the activities of senescent cells, suggesting possible contributions to future geriatric medicine.
