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Related Experiment Video

Updated: Jan 17, 2026

Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model
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Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model

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Method for generating right ventricular pressure-volume loops in routine practice.

Nils Kremer1, Felix Glocker1, Simon Schaefer1

  • 1Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|September 14, 2025
PubMed
Summary

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This summary is machine-generated.

A new method reconstructs right ventricular (RV) pressure-volume loops from routine right heart catheterization, offering reliable RV function assessment. This approach simplifies analysis, making RV PV loop evaluation more accessible for clinical use.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Physiology

Background:

  • Conductance catheterization is the gold standard for right ventricular (RV) function analysis but is complex for clinical use.
  • Routine right heart catheterization (RHC) is widely performed, offering an opportunity for simpler RV function assessment.

Purpose of the Study:

  • To validate a novel method for reconstructing RV pressure-volume (PV) loops using pressure waveforms from standard RHC.
  • To assess the reliability of this pressure-based method in estimating key RV functional parameters.

Main Methods:

  • Developed an algorithm using the hydromotive source pressure model with external calibration to estimate RV volume from pressure.
  • Validated the method against conductance catheterization in swine and patients with pulmonary hypertension.
Keywords:
Conductance catheterHemodynamicsPressure-volume loopRight heart catheterizationRight ventricular function

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  • Further validated against 3D echocardiography in patients undergoing routine RHC.

    • Main Results:

    • The pressure-based method showed very good agreement for stroke work (SW) in preclinical and clinical cohorts.
    • Moderate to good agreement was observed for end-diastolic volume (EDV) and ejection fraction (EF) compared to reference methods.
    • All estimated parameters demonstrated strong correlations with reference values (Pearson r ≥ 0.79).

    Conclusions:

    • This pressure-based method reliably reconstructs RV PV loops from standard RHC data.
    • The method accurately estimates RV stroke work, contractility, and afterload.
    • Supports integration into routine clinical workflows for enhanced RV function assessment.