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Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

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Author Spotlight: Segmentation and VR for Advanced Neurovascular Interventions

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First-in-human operations require more than technical excellence

Brent K Winemiller¹, Joshua A Daily¹, Paolla G Anderson²

¹Arkansas Children's Hospital.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation

|September 14, 2025

Summary

No abstract available in PubMed .

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