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Updated: Jul 13, 2026

Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

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Water-soluble hydroxypropyl curdlan derivatives with thermosensitive properties.

Gabriela L Ailiesei¹, Irina Popescu¹, Mihaela Avadanei¹

¹"Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley 41A, 700487 Iasi, Romania.

Carbohydrate Polymers

|September 14, 2025

Summary

Hydroxypropyl curdlan (HPCD) derivatives were synthesized to improve curdlan

Keywords:

ATR-FTIR with temperature variation Hydroxypropyl curdlan Molecular substitution NMR Thermo-responsiveness

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Published on: July 4, 2017

Area of Science:

Polymer Chemistry
Biomaterials Science

Background:

Curdlan, a bacterial polysaccharide, is poorly soluble in common solvents.
Developing soluble and functional curdlan derivatives is essential for broader applications.

Purpose of the Study:

To synthesize hydroxypropyl curdlan (HPCD) derivatives.
To investigate the structure-property relationships, focusing on water solubility and thermo-responsive behavior.

Main Methods:

Homogeneous etherification of curdlan with propylene oxide.
Characterization using NMR spectroscopy (¹H, ¹³C, DEPT135, 2D HSQC).
Thermal behavior analysis via rheology, turbidimetry, and ATR-FTIR spectroscopy.

Main Results:

HPCD derivatives exhibit water solubility above a substitution degree of 1.
Thermo-responsive characteristics were observed due to the balance of hydrophilic-hydrophobic groups.
Rheological studies showed phase separation behavior similar to cellulose derivatives.
ATR-FTIR revealed selective dehydration of side chains preceding main chain dehydration during heating.

Conclusions:

Hydroxypropylation effectively enhances curdlan's water solubility and introduces thermo-responsiveness.
HPCD exhibits unique thermal phase transition behavior driven by selective dehydration processes.
These findings open avenues for novel applications of modified bacterial polysaccharides.