Multifunctional Nanofiber-Based Smart Dressing System with pH-Response, Angiogenesis, and Anti-inflammation...

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Wound Healing Technologies

Background:

• Diabetic chronic wounds suffer from persistent bacterial infections and altered pH, increasing amputation risk.
• Multifunctional and smart wound dressings are crucial for improving healing processes.
• Current treatments often fail to address the complex challenges of diabetic wound environments.

Purpose of the Study:

• To develop a multifunctional fiber film (PCSNP) for diabetic wound management.
• To integrate pH-responsive drug release and electrical stimulation for enhanced healing.
• To create a smart dressing that indicates wound status and promotes tissue regeneration.

Main Methods:

• Fabrication of a three-layer electrospun fiber film (PCSNP) with distinct functionalities.
• Incorporation of pH-responsive elements for controlled drug delivery.
• Evaluation of electrical stimulation, antibacterial activity, and biocompatibility.
• Assessment of cellular proliferation, migration, anti-inflammation, and angiogenesis promotion.

Main Results:

• PCSNP generated 1.6 V electrical stimulation, enhancing cell growth.
• Demonstrated high antibacterial efficacy against common wound pathogens (e.g., S. aureus, E. coli, P. aeruginosa, MRSA).
• Showcased significant promotion of cell proliferation, migration, anti-inflammation, and angiogenesis.
• Exhibited color-changing properties for wound status indication and rapid drug release upon contact.

Conclusions:

• The developed PCSNP fiber film effectively addresses multiple challenges in diabetic wound healing.
• This smart, multifunctional dressing shows promise for improving therapeutic outcomes and reducing amputation rates.
• PCSNP represents a significant advancement in smart wound dressing technology for chronic wound management.