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Updated: Jan 17, 2026

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
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Advances in the Mechanism of ceRNA Regulation in Postoperative Cognitive Dysfunction

Qiang Liu1, Lin-Hui Ma2, Chen-Rui Zhou3

  • 1Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China.

Current Neuropharmacology
|September 15, 2025
PubMed

Insights

Postoperative cognitive dysfunction (POCD) involves cognitive decline after surgery. This review explores non-coding RNAs and the ceRNA mechanism as potential therapeutic targets for POCD.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Postoperative cognitive dysfunction (POCD) is a frequent neurological complication in older surgical patients, impacting memory, attention, and personality.
  • Current treatments for POCD are limited, highlighting the need for novel therapeutic strategies and a deeper understanding of its underlying molecular mechanisms.

Purpose of the Study:

  • This review aims to elucidate the role of non-coding RNAs (ncRNAs) and the competing endogenous RNA (ceRNA) mechanism in the pathogenesis of POCD.
  • To provide a foundation for future research into mechanistic exploration and the development of targeted therapies for POCD.

Main Methods:

  • A comprehensive review of existing scientific literature on ncRNAs, ceRNA networks, and their involvement in POCD.
  • Analysis of emerging evidence linking ceRNA-mediated regulatory pathways to POCD development and progression.

Main Results:

  • Non-coding RNAs are crucial regulators of neuronal complexity and synaptic function in the central nervous system.
  • The ceRNA mechanism, where ncRNAs modulate microRNA (miRNA) activity, is implicated in the gene expression dysregulation observed in POCD.

Conclusions:

  • ceRNA regulatory networks represent a promising area for understanding POCD pathogenesis.
  • Targeting ncRNA-mediated ceRNA pathways offers potential for developing novel therapeutic interventions for postoperative cognitive dysfunction.
Keywords:
Postoperative cognitive dysfunctioncentral nervous systemcircular RNAcompeting endogenous RNAslong non-coding RNAmicroRNA

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