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Influence of Different Parameters on the Labeling Efficiency of Technetium-99m Radiopharmaceuticals: Kuwait Nuclear
Fatma J Al-Saeedi1, Zainab S Al-Qallaf2, Shatha N Khalaf3
1Department of Nuclear Medicine, College of Medicine, Kuwait University, Jabriya, Kuwait, fatma.alsaeedi@ku.edu.kw.
Objectives:
The objective of this study was to evaluate the effects of temperature, light, pH, reducing agents, oxygen, dilution, syringe material, solvents, and operator differences on the labeling efficiency of 99mTc-radiopharmaceuticals.
Methods:
Five GE Healthcare kits ([99mTc]Tc-HMPAO, [99mTc]Tc-MAA, [99mTc]Tc-DMSA, [99mTc]Tc-DTPA, and [99mTc]Tc-tin colloid) were reconstituted with 99mTc-pertechnetate in saline and tested under varying conditions.
Results:
Labeling efficiency was largely unaffected, except for [99mTc]Tc-HMPAO, which showed significant reductions with temperature changes (p < 0.001). UV light significantly degraded labeling in all kits (p < 0.001), and pH changes reduced [99mTc]Tc-DMSA efficiency.
Conclusion:
Stability depends on optimized formulation, storage, and preparation, and shelf-life extension may be feasible under controlled conditions.
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