Related Experiment Video
Updated: Jun 30, 2026

Morphometric Analyses of Retinal Sections
Published on: February 19, 2012
Neuroprotective Properties of Citicoline in Patients with Unexplained Visual Acuity Loss Related to Silicone Oil
Aims:
To review the findings in the professional literature on unexplained loss of visual acuity (VA) in patients with silicone oil (SO) tamponade and post-removal, and assess the efficacy and safety of citicoline as a neuroprotective agent on anatomical changes and visual function in patients undergoing 25-gauge pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment with large/multiple tears (macula-on/off).
Materials And Methods:
We studied 96 eyes, 64 receiving citicoline (5 ml orally 3x daily) after PPV with SO tamponade, performed from 01.01.2023 to 30.06.2023 at the Eye Clinic of SZU and UNB. Best corrected visual acuity (BCVA) was measured using ETDRS charts, and changes in the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) were assessed using OCT at 1, 3 and 6 months. Complications were monitored and results analyzed statistically.
Results:
BCVA improved (citicoline: 19 to 48 letters; non-citicoline: 13 to 42 letters, p.
Related Concept Videos
Glaucoma: Overview
Photoreceptors and Visual Pathways
Olfactory Receptors: Location and Structure
Diabetic Retinopathy
Hepatic Encephalopathy

