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Study on serum tRF-30-RRJ89O9NF5W8 as a potential biomarker for clinical diagnosis of gastric cancer

  • 0Department of Laboratory Medicine, Affiliated Hospital of Nantong University Nantong 226001, Jiangsu, P. R. China.
American Journal of Cancer Research +

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September 15, 2025

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September 15, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

A novel tRNA-derived small RNA (tsRNA), tRF-30-RRJ89O9NF5W8, is significantly downregulated in gastric cancer (GC) serum. This biomarker shows potential for early GC detection and monitoring treatment efficacy.

Area Of Science

  • Oncology
  • Molecular Biology
  • Biochemistry

Background

  • Gastric cancer (GC) remains a leading cause of cancer mortality globally.
  • Early detection and accurate diagnosis are critical for improving GC patient outcomes.
  • Novel biomarkers are needed to enhance GC diagnosis and management.

Purpose Of The Study

  • To identify and validate a specific tRNA-derived small RNA (tsRNA) as a diagnostic biomarker for gastric cancer (GC).
  • To assess the expression levels of tRF-30-RRJ89O9NF5W8 in GC patients' serum and correlate it with clinicopathological features.

Main Methods

  • Development and validation of a methodology to quantify tRF-30-RRJ89O9NF5W8 expression in serum.
  • Analysis of tRF-30-RRJ89O9NF5W8 expression in GC patients, individuals with gastritis, and healthy controls.
  • Correlation analysis between tRF-30-RRJ89O9NF5W8 levels and clinicopathological parameters (TNM stage, T stage, invasion).

Main Results

  • tRF-30-RRJ89O9NF5W8 expression was significantly downregulated in the serum of GC patients compared to controls.
  • Expression levels increased post-radical surgery, indicating a response to treatment.
  • tRF-30-RRJ89O9NF5W8 levels correlated with TNM stage, T stage, and neural/vascular invasion.
  • The biomarker demonstrated superior diagnostic performance compared to existing markers.

Conclusions

  • tRF-30-RRJ89O9NF5W8 is a promising candidate diagnostic biomarker for gastric cancer.
  • Its downregulation in serum and correlation with disease progression support its utility.
  • This tsRNA may also hold potential as a therapeutic target for GC.

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