Related Experiment Video
Updated: Jan 17, 2026

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
Published on: August 8, 2025
Skin immune microenvironment in psoriasis: from bench to bedside.
Yi Yao1, Li-Qing Chen1, Yi-Bo Lv1
1Department of Dermatology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, China.
Psoriasis is a complex skin disease driven by immune system dysfunction and environmental factors. Understanding the skin's immune microenvironment is key to developing new treatments for psoriasis patients.
Area of Science:
- Immunology
- Dermatology
- Genetics
Background:
- Psoriasis is a chronic, immune-mediated skin disorder affecting 2-3% of the global population.
- Pathogenesis involves genetic, epigenetic, and environmental factors disrupting immune homeostasis.
- The epithelial immune microenvironment (EIME) plays a critical role in psoriasis.
Purpose of the Study:
- To review the fundamental mechanisms of psoriasis from a 'bench' perspective.
- To discuss translational research linking basic science discoveries to clinical applications.
- To evaluate current and emerging treatments for psoriasis.
Main Methods:
- Review of genetic triggers, immune cell contributions, and cytokine cascades.
- Analysis of multi-omics studies, gut microbiota, and neuro-immunological influences.
- Evaluation of clinical applications, biomarkers, comorbidities, and therapeutic modalities.
Main Results:
- Complex interplay of genetic, epigenetic, and environmental factors drives psoriasis.
- Multi-omics studies and emerging areas like gut dysbiosis offer new insights.
- Various treatments exist, including biologics and novel agents like JAK inhibitors.
Conclusions:
- The skin's immune microenvironment is central to psoriasis pathogenesis.
- Translational research is advancing psoriasis treatment and personalized medicine.
- Future directions include multi-omics integration and holistic immune targeting for improved outcomes.
Related Concept Videos
Clinical Applications of Epidermal Stem Cells
iPS Cell Differentiation
EPS and iPS Cells in Disease Research
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

