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Preoperative interleukin-17a as a predictor of acute pancreatitis after pancreaticoduodenectomy

  • 0Department of Pancreatology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, China.
World Journal of Gastrointestinal Surgery +

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September 15, 2025

|

September 15, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Preoperative Interleukin-17A (IL-17a) levels can predict acute pancreatitis (AP) after pancreaticoduodenectomy (PD). Combining IL-17a with fluid load status improves prediction accuracy for AP and postoperative pancreatic (PP) complications.

Area Of Science

  • Surgical Oncology
  • Gastroenterology
  • Immunology

Background

  • Acute pancreatitis (AP) is a severe complication following pancreaticoduodenectomy (PD).
  • Interleukin-17A (IL-17a) is explored as a potential biomarker for predicting postoperative outcomes.
  • Identifying predictive markers is crucial for managing AP and postoperative pancreatic (PP) complications.

Purpose Of The Study

  • To evaluate the prognostic value of preoperative IL-17a levels.
  • To assess the predictive capability of IL-17a for AP and PP after PD.
  • To determine if IL-17a combined with fluid load status enhances prediction accuracy.

Main Methods

  • Retrospective analysis of 150 patients undergoing PD (2017-2023).
  • Collection of pre-operative IL-17a levels and intraoperative fluid load data.
  • Statistical evaluation of IL-17a and fluid load for predicting AP and PP.

Main Results

  • 17.3% developed postoperative AP and 22.7% developed PP.
  • Preoperative IL-17a levels were a significant risk factor for postoperative AP (P=0.03).
  • Excessive intraoperative fluid load was associated with PP (P=0.01); combined model showed high accuracy.

Conclusions

  • Preoperative IL-17a levels and intravascular volume status are potential predictors of AP and PP after PD.
  • These markers aid in preoperative risk assessment.
  • Clinical decision-making can be guided to improve postoperative recovery.

Keywords:

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