Related Experiment Video
Updated: Jan 17, 2026
12:22
The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
34.1K
Correlation Between Vancomycin Trough Concentrations and C-Reactive Protein in Neonates: A Retrospective
Bo Guo1, Hui Chen1, Xiao Song1
1Department of Pharmacy, Northwest Women's and Children's Hospital, Xi'an, People's Republic of China.
Infection and Drug Resistance
|September 15, 2025
Summary
Low initial vancomycin trough concentrations (TCV) in neonates are common. This study found a non-linear relationship between C-reactive protein (CRP) and initial TCV, with a negative correlation when CRP exceeds 88.28 mg/L.
Area of Science:
- Neonatal pharmacology
- Clinical chemistry
- Pharmacokinetics
Background:
- Low initial trough concentrations of vancomycin (TCV) are frequently observed in neonates.
- Previous studies linked TCV to factors like age, weight, and renal function.
- The relationship between C-reactive protein (CRP) and initial TCV in neonates remains under-explored.
Purpose of the Study:
- To investigate the correlation between C-reactive protein (CRP) levels and initial vancomycin trough concentrations (TCV) in a Chinese neonatal population.
- To determine if CRP is a predictor of initial TCV in neonates.
Main Methods:
- Retrospective observational study of 112 neonates receiving intravenous vancomycin.
- Data collected within 24 hours prior to the first vancomycin dose.
- Analysis focused on C-reactive protein (CRP) levels and initial vancomycin trough concentrations (TCV).
Main Results:
- A non-linear relationship was identified between CRP and initial TCV.
- An inflection point was observed at a CRP level of 88.28 mg/L.
- A negative correlation between CRP and initial TCV was found when CRP levels exceeded 88.28 mg/L.
Conclusions:
- A significant non-linear association exists between CRP and initial TCV in neonates.
- Elevated CRP levels (above 88.28 mg/L) are associated with lower initial vancomycin trough concentrations.
- CRP may serve as a potential indicator for monitoring vancomycin dosing in neonates.
