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Updated: Jan 17, 2026

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BRD2 Upregulation as a Pan-Cancer Adaptive Resistance Mechanism to BET Inhibition

Suyakarn Archasappawat1,2, Juliette Jacques1, EunJung Lee1

  • 1Department of Microbiology and Molecular Genetics, College of Biological Sciences, University of California, Davis, CA.

Biorxiv : the Preprint Server for Biology
|September 15, 2025
PubMed
Summary

Bromodomain and extraterminal motif (BET) inhibitors show promise in cancer treatment. Upregulation of BRD2 was identified as a mechanism of resistance to BET inhibitors, suggesting co-targeting BRD2 could improve cancer therapy efficacy.

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