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Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
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Coronavirus NSP14 Drives Internal m 7 G Modification to Rewire Host Splicing and Promote Viral Replication

Ensueño Esmeralda Sáenz Altamirano, Chien-Hsin Huang, Yueh-Lin Tsai

    Biorxiv : the Preprint Server for Biology
    |September 15, 2025
    PubMed
    Summary

    SARS-CoV-2 uses its NSP14 protein to add N7-methylguanosine (m7G) modifications to host mRNA, disrupting gene expression and aiding viral replication. Inhibiting this m7G modification halts virus spread, offering a new therapeutic target.

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