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Risk factors for comorbid hypertension in elderly patients with type 2 diabetes
Wei-Xian Zheng1, Ping Liao1, Li-Li Luo1
1Beijing Jishuitan Hospital Guizhou Hospital Guiyang 550014, Guizhou, China.
American Journal of Translational Research
|September 15, 2025
Summary
Hypertension risk in elderly diabetics is linked to longer disease duration, alcohol use, inactivity, and abnormal cholesterol and kidney markers. Combined factors strongly predict hypertension development.
Area of Science:
- Gerontology
- Cardiology
- Endocrinology
Background:
- Elderly patients with diabetes mellitus face increased risks for cardiovascular complications.
- Hypertension (HT) is a prevalent comorbidity in this population, necessitating identification of specific risk factors.
Purpose of the Study:
- To identify and analyze the risk factors associated with hypertension in elderly individuals diagnosed with diabetes mellitus.
- To evaluate the predictive utility of identified risk factors for hypertension in this demographic.
Main Methods:
- Retrospective analysis of 139 elderly diabetic patients (61 HT, 78 non-HT).
- Comparison of demographic, lifestyle, and serum biochemical markers between groups.
- Binary logistic regression and Receiver Operating Characteristic (ROC) analysis to identify and assess risk factors.
Main Results:
- Hypertension group showed older age, longer diabetes duration, higher LDL-C, and more cardio-cerebrovascular events.
- Significant risk factors included disease duration, alcohol consumption, exercise frequency, HDL-C, LDL-C, uric acid (UA), and microalbuminuria.
- A combined model of these factors achieved a high predictive accuracy (AUC = 0.910).
Conclusions:
- Prolonged diabetes duration, alcohol consumption, physical inactivity, and abnormal lipid profiles (low HDL-C, high LDL-C) are key hypertension risk factors.
- Elevated uric acid and microalbuminuria also significantly contribute to hypertension risk in this population.
- Combined assessment of these factors offers robust predictive value for identifying hypertension risk in elderly diabetics.
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