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Updated: Jan 17, 2026
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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
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Unlocking the Prognostic Potential of Right Ventricular Strain in Heart Failure Subtypes
Aly Saad1, Mohammad Abdelhady1, Loai Ali AbdulHadi Attia2
1Department of Cardiovascular Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Journal of Cardiovascular Echography
|September 15, 2025
Summary
Right ventricle global longitudinal strain (RV GLS) effectively predicts poor outcomes in heart failure (HF) patients. A cutoff of -14.7% shows promise for risk stratification and guiding interventions in diverse HF types.
Area of Science:
- Cardiology
- Echocardiography
- Heart Failure Research
Background:
- Right ventricle (RV) function is critical for heart failure (HF) prognosis across various etiologies.
- RV dysfunction's impact on HF with preserved (HFpEF), mid-range (HFmrEF), and reduced ejection fraction (HFrEF) is increasingly recognized.
Purpose of the Study:
- To evaluate right ventricle global longitudinal strain (RV GLS) as an early and sensitive predictor of outcomes in HF patients.
- To assess RV GLS's predictive value across different HF subtypes categorized by ejection fraction (EF).
Main Methods:
- Prospective study of 100 HF patients divided into HFpEF, HFmrEF, and HFrEF groups.
- Standardized echocardiographic assessment including RV GLS measurement.
- Outcomes defined by major adverse cardiac events (MACE) and worsening functional status.
Main Results:
- RV GLS differed significantly across HF groups, being markedly lower in HFrEF patients compared to HFpEF and HFmrEF.
- RV GLS showed a sensitivity of 75% and specificity of 69.12% for predicting poor outcomes.
- A cutoff threshold of -14.7% for RV GLS was identified.
Conclusions:
- RV GLS is a reliable marker for predicting adverse outcomes in heart failure patients.
- The identified RV GLS cutoff of -14.7% aids in risk stratification.
- RV GLS offers clinical utility for timely intervention strategies in HF management.
Keywords:
Global longitudinal strainN-terminal pro B-type natriuretic peptideheart failureprognosisright ventricleMore Related Videos
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