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Disorders of Leukocytes

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...

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KIT-Negative Systemic Mastocytosis Associated With Acute Myeloid Leukemia.

Kabeer Ali¹, Tasnuva Rashid², Jennifer Miatech³

¹Department of Medicine, University of Florida College of Medicine: Jacksonville, Jacksonville, Florida, USA.

Case Reports in Oncological Medicine

|September 15, 2025

Summary

This study presents a rare case of KIT-negative systemic mastocytosis (SM) linked with acute myeloid leukemia (AML). Treatment with azacitidine and venetoclax showed reduced mastocytosis but not full hematologic recovery.

Area of Science:

Hematology
Oncology
Rare Diseases

Background:

Systemic mastocytosis (SM) involves abnormal mast cell proliferation.

Keywords:

KIT mutation SM-AHN mast cell systemic mastocytosis systemic mastocytosis associated with hematologic non-MC lineage disease

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SM can manifest with diverse symptoms and is often associated with a KIT mutation.

Rarely, SM co-occurs with other hematologic neoplasms, such as acute myeloid leukemia (AML).