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Updated: Jan 17, 2026

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Valvular Heart Disease Associations with Cardiac Biomarkers Using AI-guided Echocardiography: the RURAL Cohort Study.

Evangelia Alexopoulos1, Joanna Walsh2, Jesse Y Hsu2

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|September 15, 2025
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Summary

Mitral valve prolapse (MVP) and valvular heart disease (VHD) prevalence in the rural US South was assessed. Higher cardiovascular disease risk scores were linked to increased VHD odds, and severe MVP correlated with elevated NTproBNP levels.

Keywords:
Mitral valve prolapsebiomarkersrural countiesvalvular heart disease

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Area of Science:

  • Cardiology
  • Epidemiology
  • Public Health

Background:

  • Limited data exists on mitral valve prolapse (MVP) and valvular heart disease (VHD) prevalence in the rural US South.
  • Early detection strategies are vital for risk stratification and prevention in this population.

Purpose of the Study:

  • To determine the prevalence of MVP and other VHD in a rural Southern US cohort.
  • To examine associations between MVP/VHD and cardiovascular disease (CVD) risk.
  • To evaluate the relationship between MVP severity and cardiac biomarkers (hsTnT, NTproBNP).

Main Methods:

  • Cross-sectional analysis of the Risk Underlying Rural Areas Longitudinal (RURAL) study.
  • Logistic regression to assess associations between participant characteristics and MVP/VHD.
  • Weighted models using the Predicting Risk of CVD Events (PREVENT) score to evaluate MVP/VHD odds by CVD risk categories.
  • Subset analysis of MVP severity and cardiac biomarkers.

Main Results:

  • MVP and other VHD were found in 1.9% and 11.2% of 2,621 participants, respectively.
  • Higher PREVENT risk scores were associated with lower odds of MVP and higher odds of other VHD.
  • Lower hsTnT in MVP vs. non-MVP; higher NTproBNP in severe MVP vs. non-MVP.

Conclusions:

  • MVP prevalence is consistent with population-based studies.
  • The PREVENT score may help identify individuals at higher risk for MVP and other VHD.
  • Further research is needed to link MVP/VHD status to clinical outcomes.