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Advancing bioinformatics capacity through Nextflow and nf-core: lessons from an early-to mid-career
Patricia Agudelo-Romero1,2,3, Talya Conradie1, Jose Antonio Caparros-Martin1,4,5
1Wal-Yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, WA, Australia.
Abstract:
The increasing adoption of high-throughput "omics" technologies has heightened the demand for standardized, scalable, and reproducible bioinformatics workflows. Nextflow and nf-core provide a robust framework for researchers, particularly early- and mid-career researchers (EMCRs), to navigate complex data analysis. At The Kids Research Institute Australia, we implemented a structured approach to bioinformatics capacity building using these tools. This perspective presents nine practical rules derived from lessons learnt, which facilitated the successful adoption of Nextflow and nf-core, addressing implementation challenges, knowledge gaps, resource allocation, and community support. Our experience serves as a guide for institutions aiming to establish sustainable bioinformatics capabilities and empower EMCRs.
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