Related Experiment Video
Updated: Jul 12, 2026
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Favorable Outcome of Nasal-Type Extranodal Natural Killer (NK)/T-Cell Lymphoma in a Very Elderly Patient Treated With
Natsumi Hara1, Natsuko Saito-Sasaki1, Etsuko Okada1
1Dermatology, University of Occupational and Environmental Health, Kitakyushu, JPN.
Abstract:
Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL), is a rare and aggressive Epstein-Barr virus (EBV)-associated malignancy, typically affecting middle-aged individuals. Cases in patients over 80 are extremely rare. We report an 88-year-old woman, the oldest known case, successfully treated with radiotherapy alone. She presented with erythema and swelling of the right cheek and nasal cavity, initially misdiagnosed as facial cellulitis. A skin biopsy revealed atypical CD3⁺/CD56⁺ lymphoid cells, and EBER positivity confirmed EBV involvement. Imaging showed localized disease without systemic spread. Due to her advanced age and comorbidities, chemotherapy was not feasible, and she received radiotherapy alone, resulting in complete remission without recurrence. This case highlights the effectiveness of radiotherapy in localized ENKTCL and suggests that even very elderly patients can achieve favorable outcomes with appropriate treatment.
Related Concept Videos
01:28Cells of the Innate Immune Response
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
01:27Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...