Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mismatch Repair01:20

Mismatch Repair

6.3K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
6.3K
Mismatch Repair01:36

Mismatch Repair

43.5K
Overview
43.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of muscle forces on rotational and cranio-caudal stability in the intact and CCL-deficient stifle: An ex vivo biomechanical study.

Veterinary surgery : VS·2026
Same author

Clinical Outcomes and Patterns of Neurological Toxicity After Stereotactic Body Radiotherapy Reirradiation (reSBRT) of Spine Metastases Previously Treated with SBRT.

Cancers·2026
Same author

Genomic Characterization of Lung Cancer in Never-Smokers Using Deep Learning.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
Same author

The effects of foraminotomy and distraction-stabilization on the dimensions of the lumbosacral neuroforamen throughout range of motion.

Veterinary journal (London, England : 1997)·2026
Same author

Investigating the relationship between breast cancer risk factors and an AI-generated mammographic texture feature in the Nurses' Health Study II.

NPJ breast cancer·2025
Same author

Leveraging large language models for structured information extraction from pathology reports.

Journal of pathology informatics·2025

Related Experiment Video

Updated: Jan 17, 2026

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.6K

mSigSDK - private computation of mutation signatures.

Aaron Ge1,2, Tongwu Zhang1, Yasmmin Côrtes Martins3

  • 1-Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, USA.

Research Square
|September 15, 2025
PubMed
Summary

We developed mSigSDK, a JavaScript Software Development Kit (SDK), for in-browser mutational signature analysis. This tool enables secure, private analysis of patient data without downloads, enhancing cancer research accessibility.

More Related Videos

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

5.1K
Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
06:59

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter

Published on: March 31, 2022

2.8K

Related Experiment Videos

Last Updated: Jan 17, 2026

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.6K
Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

5.1K
Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
06:59

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter

Published on: March 31, 2022

2.8K

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Web Technologies

Background:

  • Previous work established feasibility of privacy-preserving mutation signature analysis without downloads.
  • Need for accessible tools to orchestrate distributed data processing and visualization in mutational signature analysis.

Purpose of the Study:

  • To develop an in-browser Software Development Kit (SDK) named mSigSDK.
  • To facilitate distributed data processing workflows and visualization of mutational signature analysis results.
  • To ensure secure, private, and accessible analysis of individual patient data.

Main Methods:

  • Developed mSigSDK using modern web computing standards (ECMAScript ES6 modules).
  • Implemented in-browser computation via secure delegation to user's machine resources.
  • Focused on FAIR (Findable, Accessible, Interoperable, Reusable) extensibility.

Main Results:

  • mSigSDK enables fully in-browser mutational signature analysis.
  • The SDK supports distributed data processing and graphical visualization.
  • Analysis is performed securely on the user's local machine without downloads or installations.

Conclusions:

  • mSigSDK provides a secure, private, and efficient platform for mutational signature analysis.
  • The SDK enhances accessibility for researchers by eliminating download requirements.
  • mSigSDK is extensible and aims to support integration with other mutation signature API ecosystems, fostering a data commons for research.