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Monolithic three-dimensional neural probes from deterministic rolling of soft electronics.

Yi Qiang1, Wen Gu2,3, Dongyeol Jang1

  • 1Thayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.

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Researchers developed novel 3D neural probes using a unique rolling method. This technology enables high-density neural recordings in the brain, advancing our understanding of cognition and behavior.

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Area of Science:

  • Neuroscience
  • Bioengineering
  • Materials Science

Background:

  • Neural circuits supporting cognition and behavior are 3D.
  • Existing neural probes are typically 2D due to fabrication limitations.
  • This limits comprehensive neural activity recording.

Purpose of the Study:

  • To develop scalable, flexible monolithic 3D neural probes.
  • To overcome the limitations of 2D neural recording interfaces.
  • To enable high-resolution 3D spatiotemporal mapping of neural activity.

Main Methods:

  • A novel 'rolling-of-soft-electronics' approach was employed.
  • Planar flexible electrode devices were deterministically rolled into 3D structures.
  • Device design variations (shank pitch, spacer thickness) allowed versatile 3D probe configurations with hundreds of electrodes.

Main Results:

  • Demonstrated in vivo single-unit spike recording in rodent and non-human primate models.
  • Achieved microscopy-like 3D spatiotemporal mapping of neural spike activity in the rodent visual cortex.
  • Showcased five-week recording stability and effective 3D decoding of visual orientation.

Conclusions:

  • The rolling-of-soft-electronics method offers a scalable and flexible approach for fabricating monolithic 3D neural probes.
  • These 3D probes significantly enhance neural recording capabilities, enabling detailed 3D spatiotemporal mapping.
  • The technology holds promise for advancing neuroscience research and understanding brain function.