Related Experiment Video

Updated: Jan 17, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.0K

Effects of statins on serum sCD40, sCD146 and PAPP-An in patients with coronary heart disease

Huawen Li1, Xia Zhou1, Wenyan Zhu1

  • 1South the Taihu Lake Hospital, Huzhou University, Department of Cardiology, Zhejiang Province, China.

Journal of Medical Biochemistry
|September 15, 2025
PubMed

Insights

Statins significantly improve cardiac function and lipid levels in coronary heart disease patients. They also effectively regulate sCD40, sCD146, and PAPP-A levels, showing better outcomes than standard treatment.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Coronary heart disease (CHD) poses significant health risks.
  • Biomarkers such as sCD40, sCD146, and PAPP-A are implicated in CHD.
  • Statins are widely used for cardiovascular disease management.

Purpose of the Study:

  • To investigate the efficacy of statins (Atorvastatin and Rosuvastatin) in managing CHD.
  • To analyze the impact of statins on specific biomarkers: sCD40, sCD146, and PAPP-A.
  • To compare the effects of statins versus standard care on cardiac function and lipid profiles.

Main Methods:

  • A study involving 126 CHD patients from September 2022 to September 2024.
  • Patients were divided into a control group (standard treatment) and a study group (statin treatment).
  • The study group received either Atorvastatin or Rosuvastatin (20 mg daily for 3 months), alongside standard care.

Main Results:

  • Both statin groups showed significant improvements in cardiac function and blood lipid levels compared to the control group.
  • Serum levels of sCD40, sCD146, and PAPP-A were significantly reduced in statin-treated patients versus the control group.
  • No significant difference in biomarker levels was observed between Atorvastatin and Rosuvastatin groups.

Conclusions:

  • Statins (Atorvastatin and Rosuvastatin) are effective in improving cardiac function and lipid profiles in CHD patients.
  • Statin therapy demonstrates a beneficial effect on regulating sCD40, sCD146, and PAPP-A levels in CHD.
  • Statins offer superior therapeutic benefits for CHD compared to standard cardiotonic treatments.
Abstract

Keywords:
PAPP-Ancoronary heart diseasesCD146serum factorserum sCD40statins

More Related Videos

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

14.1K
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.7K

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.3K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
590
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
322
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
399
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
215
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
890