Efficacy of Encorelane in Enhancing Barrier Function and Reducing Aging Signs in Sensitive Skin

Area of Science:

• Dermatology and Cosmetic Science
• In vitro and In vivo Efficacy Studies
• Skin Barrier and Aging Research

Background:

• Sensitive skin requires specialized care to enhance barrier function and reduce inflammation.
• Visible aging signs necessitate interventions for collagen synthesis and skin matrix support.

Purpose of the Study:

• To evaluate the efficacy of Encorelane, a novel blend of saccharide isomerate, ribose, and fructooligosaccharides.
• To assess Encorelane's impact on sensitive skin markers and visible aging signs.

Main Methods:

• In vitro assessment using a 3D epidermal model (EpiKutis) with Sodium Lauryl Sulfate (SLS) induction to measure cytokines and barrier markers.
• In vitro evaluation of hydration via aquaporin 3 (AQP3) expression and anti-wrinkle efficacy against UVA/UVB exposure.
• In vivo 6-week double-blind, half-face study in 23 sensitive-skin subjects evaluating clinical effects versus placebo.

Main Results:

• In vitro: Encorelane significantly reduced pro-inflammatory cytokines (IL-1α, TNF-α, IL-6, IL-8, PGE2) and increased barrier markers (FLG, LOR, TGM1) and hydration (AQP3).
• In vitro: Significant increases in collagen types I, III, IV, VII, XVII, and laminin 5 were observed, indicating anti-aging potential.
• In vivo: Encorelane significantly improved transepidermal water loss (TEWL), redness (R2), firmness (F4), and crow's feet wrinkles compared to placebo.

Conclusions:

• Encorelane demonstrates significant efficacy in targeting both inflammation and aging signs in sensitive skin.
• The ingredient blend supports enhanced skin barrier function and hydration.
• Encorelane presents a viable dermocosmetic solution for sensitive skin prone to aging.