[EEG changes with leponex medication]

Clozapin holds pharmacologically and clinically a special position among psychoactive drugs. By means of EEG examinations in 25 patients without and with Clozapin it could have been proved statistically that the distinctly marked changes can unambigously traced back to Clozapin medication. These role is in regard to localization explainable by pharmacologically assumed brain stem efficiency of the medicament. The increase of beta activity which was also found and which is not typical for neuroleptics can be explained in connection with the central anticholinerg action component.