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Risk factors for uncontrolled asthma in a pediatric population with severe asthma: FRAMAG study
Elida Duenas-Meza1,2, Sarah Pulido-Fentanes3, Monica Mendez-Moreno4,5
1Pediatric Pulmonology - Asmaire-Rexpira Program, Fundación Neumológica Colombiana, Bogotá, Colombia.
Summary
Poor asthma control in children with severe asthma is linked to sleep apnea and caregiver burden. Addressing these factors is key to improving pediatric asthma management and quality of life.
Area of Science:
- Pediatric Pulmonology
- Sleep Medicine
- Quality of Life Research
Background:
- Severe asthma in children leads to significant health issues and reduced quality of life.
- Achieving optimal asthma control in pediatric severe asthma remains a challenge despite treatment.
- Identifying factors contributing to poor asthma control is crucial for effective management.
Purpose of the Study:
- To identify clinical, functional, and caregiver-related factors associated with poor asthma control in children with severe asthma.
- To investigate the impact of comorbidities and caregiver well-being on pediatric severe asthma control.
- To inform targeted interventions for improving asthma management in children.
Main Methods:
- Retrospective cohort study of children (6-17 years) with severe asthma over three years.
- Asthma control assessed using a composite score including symptoms, exacerbations, medication use, hospitalizations, and spirometry.
- Multivariable logistic regression analysis to determine independent risk factors for uncontrolled asthma.
Main Results:
- 35.5% of children with severe asthma had uncontrolled asthma.
- Obstructive sleep apnea (OR: 2.16) and impaired caregiver quality of life (OR: 12.35) were independently associated with uncontrolled asthma.
- Higher rates of systemic corticosteroid use and prior year hospitalizations were observed in children with uncontrolled asthma.
Conclusions:
- Uncontrolled severe asthma in children is significantly associated with obstructive sleep apnea and caregiver burden.
- Multidimensional evaluations, including sleep assessment and caregiver support, are essential for optimizing pediatric asthma control.
- Longitudinal monitoring and integrated care approaches are recommended for high-risk pediatric populations.
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