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Related Experiment Videos

Left ventricular performance in subclinical hypothyroidism.

J C Forfar, C G Wathen, W T Todd

    The Quarterly Journal of Medicine
    |December 1, 1985
    PubMed
    Summary
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    Subclinical hypothyroidism, a condition with normal thyroid hormones but elevated thyrotropin, subtly impairs left ventricular function during exercise. Hormone replacement may be beneficial for these asymptomatic patients.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Thyroid Research

    Background:

    • Subclinical hypothyroidism is defined by normal plasma thyroid hormones with elevated thyrotropin levels in asymptomatic individuals.
    • Understanding the impact of subclinical hypothyroidism on cardiac function is crucial for patient management.

    Purpose of the Study:

    • To investigate left ventricular (LV) function in patients with subclinical hypothyroidism.
    • To compare LV function before and after thyroxine treatment normalized thyrotropin levels.

    Main Methods:

    • Utilized radionuclide angiography to assess LV function in 10 subclinical hypothyroid patients.
    • Evaluated resting and exercise LV ejection fraction, cardiac output response to sodium nitroprusside, and LV pressure-volume relationships.

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    Main Results:

    • Exercise LV ejection fraction was significantly lower in the subclinical hypothyroid state (61%) compared to the euthyroid state (68%).
    • Sodium nitroprusside increased cardiac output via a greater heart rate rise and stroke volume reduction in subclinical hypothyroidism versus euthyroid states.
    • End-systolic pressure-volume relationships indicated impaired LV contractility during exercise in subclinical hypothyroidism.

    Conclusions:

    • Subtle impairments in left ventricular function are detectable in subclinical hypothyroidism.
    • These findings suggest that hormone replacement therapy may be warranted in patients with subclinical hypothyroidism.