Retinal microvascular alterations in Parkinson's disease: visual analysis and meta-analysis
Shiyuan Qin1, Lei Li1, Shuang Gao1
1Department of Neurology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650031, China.
Summary
Optical coherence tomography angiography (OCTA) reveals reduced superficial capillary plexus density in Parkinson's disease (PD) patients. This noninvasive imaging shows potential for early PD diagnosis and monitoring disease progression.
Area of Science:
- Neuroscience
- Ophthalmology
- Medical Imaging
Background:
- Optical coherence tomography angiography (OCTA) is an emerging technique for assessing microvascular changes in neurodegenerative diseases.
- Retinal microvascular abnormalities have been increasingly reported in Parkinson's disease (PD).
Purpose of the Study:
- To identify research trends on OCTA application in PD using visual analysis and meta-analysis.
- To evaluate retinal blood flow alterations as a potential early diagnostic marker for PD.
Main Methods:
- Systematic literature search of PubMed, Scopus, and Web of Science.
- Visual analysis of 28 studies and meta-analysis of 19 studies using VOSviewer, CiteSpace, and RevMan 5.4.
- Analysis of keywords, research trends, and quantitative data on retinal microvasculature.
Main Results:
- Visual analysis indicated a growing research focus on OCTA in PD.
- Meta-analysis revealed a significant reduction in superficial capillary plexus (SCP) density in PD patients.
- Variable findings for deep capillary plexus (DCP) and foveal avascular zone (FAZ); correlation between microvascular density and PD severity noted.
Conclusions:
- OCTA serves as a noninvasive, objective tool for early PD diagnosis and monitoring.
- OCTA has potential clinical applications in the preclinical stages of Parkinson's disease.
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