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Tackling the Cardio-Kidney-Metabolic Burden in Cancer.

Tarek Nahle1,2, Viraj Shah3,4, Harikrishnan Hyma Kunhiraman3,4

  • 1Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA. tnahle@augusta.edu.

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Cardio-kidney-metabolic syndrome (CKMS) is a growing concern in oncology, impacting patients before and after cancer treatment. Early CKMS staging is crucial for personalized care and better patient outcomes.

Keywords:
CancerCancer therapyCardio-kidney-metabolic syndromeCardio-oncologyMetabolic syndrome

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Area of Science:

  • Oncology
  • Cardiology
  • Nephrology
  • Metabolic Medicine

Background:

  • Cardio-kidney-metabolic syndrome (CKMS) is a progressive condition affecting cardiovascular, renal, and metabolic systems.
  • Cancer therapies can exacerbate or unmask pre-existing CKMS through inflammatory and metabolic effects.

Purpose of the Study:

  • To review the clinical significance of CKMS in oncology.
  • To explore CKMS as both a comorbidity and a treatment consequence.
  • To integrate CKMS staging into personalized cancer care strategies.

Main Methods:

  • Literature review on CKMS in oncology.
  • Analysis of CKMS development and progression.
  • Evaluation of CKMS staging for risk stratification.

Main Results:

  • Cancer treatments can accelerate CKMS via inflammatory and metabolic pathways.
  • Early CKMS staging aids in monitoring, referral, and treatment.
  • A multidisciplinary, stage-based approach is vital for optimizing outcomes in patients with multimorbidity.

Conclusions:

  • Recognizing and managing CKMS is critical due to rising cancer patient multimorbidity.
  • Routine CKMS assessment in oncology facilitates early intervention.
  • Individualized care models based on CKMS stage are essential for mitigating complications and ensuring high-quality cancer care.