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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Updated: Jan 6, 2026

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
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Reproductive Autonomy in Light of Expanded Prenatal Genomic Testing.

Isabella Holmes1, Kathryn MacKay1, Rosalind McDougall2

  • 1The University of Sydney.

The American Journal of Bioethics : AJOB
|September 15, 2025
PubMed
Summary
This summary is machine-generated.

Expanded prenatal genomics offers more reproductive choices but can overlook relationships. A new framework for reproductive autonomy emphasizes relationality and adequate options for better genomic testing guidance.

Keywords:
Feminist bioethicsgenomicspregnancyprenatal diagnosisrelationalityreproductive autonomy

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Area of Science:

  • Reproductive genomics
  • Bioethics
  • Philosophy of science

Background:

  • Genomic-based testing in reproduction is rapidly expanding.
  • Current understanding of reproductive autonomy overemphasizes choice and information.
  • Existing frameworks may not adequately address the complexities of prenatal genomics.

Purpose of the Study:

  • To critically examine the concept of reproductive autonomy in the context of expanded prenatal genomics.
  • To propose a more fitting conceptualization of reproductive autonomy for prenatal genomic testing.
  • To provide philosophical context for the ethical offer and uptake of these tests.

Main Methods:

  • Critical examination of epistemological assumptions linking genomic information and autonomy.
  • Analysis of ideological pressures associated with genomic testing.
  • Development of a relational and substantivist account of reproductive autonomy.

Main Results:

  • Identified limitations in current interpretations of reproductive autonomy.
  • Proposed a relational approach to reproductive autonomy.
  • Highlighted the importance of institutional conditions and adequate options.

Conclusions:

  • A nuanced understanding of reproductive autonomy is crucial for navigating expanded prenatal genomic testing.
  • The proposed framework supports a more ethically sound approach to offering and utilizing prenatal genomic technologies.
  • Relationality and adequate options are key components of a robust reproductive autonomy in genomics.