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Risk Factors of Incidental Thyroid Abnormalities Identified on Low-Dose Chest CT Scans in Department of Energy
Khaula Khatlani1, Steven Markowitz, Mark Griffon
1From the Barry Commoner Center for Health and the Environment, Queens College, City University of New York, Flushing, New York (K.K., S.M., A. Manowitz, J.S., Y.G., A. Miller); Department of Health Sciences, Anna Maria College, Paxton, Massachusetts (M.G.); Division of Pulmonary Critical Care and Sleep Medicine, Department of Medicine (A.M.), National Jewish Health Respiratory Institute (A.M.), Icahn School of Medicine at Mount Sinai, New York, New York; Department of Radiology, VA Medical Center of New Jersey, East Orange, NJ (J.A.M.); Department of Otolaryngology-Head and Neck Surgery (M.v.G.), and Institute for Translational Epidemiology (M.v.G.), Icahn School of Medicine at Mount Sinai, New York, New York.
Objective:
We evaluated risk factors of thyroid abnormalities detected on low-dose computed tomography (LDCT) among nuclear weapons workers in a lung cancer screening program.
Methods:
We conducted a matched case-control study of participants with (647 cases) and without (1941 controls) incidental thyroid abnormalities on LDCT, matching on LDCT year and age between August 2006 and June 2023. Multivariable conditional logistic regression analysis adjusted for demographic, smoking, and occupational attributes yielded matched adjusted odds ratio (MAOR) with 95% confidence intervals.
Results:
Estimated occupational radiation exposure (medium exposure MAOR: 1.58 [1.07, 2.33] and high exposure MAOR: 1.52 [0.99, 2.33]), female (MAOR: 2.67 [2.03, 3.50]), African American (MAOR: 2.49 [1.79, 3.45]), and obesity (BMI: 30-39.9 kg/m 2 MAOR: 1.53 [1.14, 2.06], ≥40 kg/m 2 MAOR: 2.43 [1.55, 3.82]) were significantly associated with thyroid abnormalities.
Conclusion:
Further studies of occupationally exposed populations are warranted.
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