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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
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Epstein-Barr Virus in Multiple Sclerosis: Past, Present, and Future
Farah Wahbeh1,2, Joseph J Sabatino3
1Weill Cornell Medicine-Qatar, Cornell University, Qatar.
Neurology(R) Neuroimmunology & Neuroinflammation
|September 15, 2025
Summary
Epstein-Barr virus (EBV), a common herpesvirus, is linked to multiple sclerosis (MS). This review explores how EBV affects B cells and immunity, potentially causing MS through various mechanisms.
Area of Science:
- Virology
- Immunology
- Neurology
Background:
- Epstein-Barr virus (EBV) infects over 90% of the global population.
- EBV is a known risk factor for developing multiple sclerosis (MS).
- The precise mechanisms linking EBV to MS pathogenesis remain unclear.
Purpose of the Study:
- To review how EBV impacts B cell function, the virus's main reservoir.
- To examine the dysregulation of anti-EBV immunity in MS patients.
- To explore potential EBV-driven mechanisms in MS development, including driver and hit-and-run models.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of EBV's effects on B cell biology.
- Examination of immune responses in the context of MS and EBV infection.
Main Results:
- EBV significantly alters B cell functions.
- Anti-EBV immunity is dysregulated in individuals with MS.
- Evidence supports multiple potential pathways for EBV-induced MS, such as driver and hit-and-run models.
Conclusions:
- Understanding EBV's role in MS requires further investigation into B cell alterations and immune dysregulation.
- Clarifying EBV's contribution to MS pathogenesis is crucial for developing targeted therapies.
- Outstanding scientific questions need addressing to advance MS research and treatment.
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